Physiopathology of gout
نویسندگان
چکیده
Introduction Gout can be defined as the presence of monosodium urate crystals (MSUCs) in tissues. These MSUCs may induce acute inflammation when shed into the synovial fluid or cause aggregate-inducing chronic tissue inflammation. The nucleation and formation of MSUCs is related to the presence of longstanding hyperuricemia, which is an essential factor in the development of gout. Other factors, such as level of hyperuricemia, time exposed to hyperuricemia, and genetic or acquired tissue predisposition for the nucleation of MSUCs, may explain why not all patients with hyperuricemia develop gout, or why some patients develop early or rapidly progressive symptoms associated with gout.
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